The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
Background
MicroRNAs are involved in the regulation of spermatogenesis, are detected in semen and may be useful as molecular markers for predicting residual complete spermatogenesis in azoospermic men.
Objectives
To study the biomarker potential of microRNAs that are detected in semen and testicular tissue.
Materials and methods
MicroRNA profiles were analyzed in semen fractions of normozoospermic...
Background
Adenosine deaminase domain containing 2 (ADAD2) is a testis‐specific protein composed of a double‐stranded RNA binding domain and a non‐catalytic adenosine deaminase domain. A recent study showed that ADAD2 is indispensable for the male reproduction in mice. However, the detailed functions of ADAD2 remain elusive.
Objectives
This study aimed to investigate the cause of male sterility...
Background
Germ granules are large cytoplasmic ribonucleoprotein complexes that emerge in the germline to participate in RNA regulation. The two most prominent germ granules are the intermitochondrial cement (IMC) in meiotic spermatocytes and the chromatoid body (CB) in haploid round spermatids, both functionally linked to the PIWI‐interacting RNA (piRNA) pathway.
Aims
In this study, we clarified...
Background
Exposure to heat waves could result in adverse effects on human health, especially in male testicles. PIWI‐interacting RNA (piRNA) is a novel type of small non‐coding RNA, which can notably impact mRNA turnover and preserve germline maintenance in germline cells. However, piRNA's expression status when adapting to testicular heat stress remains largely unclear.
Objectives
To investigate...
Despite excellent outcomes with modern multidisciplinary care, clinicians caring for patients with testicular germ cell tumour (TGCTs) face clinical dilemmas across the spectrum of disease. Wrong treatment choices can lead to undertreatment or overtreatment of these young men. Unfortunately the currently available biomarkers alpha‐fetoprotein and human chorionic gonadotropin, lack sufficient sensitivity...
Background
RNA harbored by mammalian sperm is increasingly considered to be an additional source of paternal hereditary information, beyond DNA. Recent studies have demonstrated the role of sperm small noncoding RNAs (sncRNAs) in modulating early embryonic development and offspring phenotype. The biogenesis of the sperm sRNA payload of mammalian sperm has been explored in many studies.
Aims
To...
Background
Specific cancer types face specific clinical management challenges. Owing to their stability, robustness and fast, easy and cost‐effective detection, microRNAs (miRNAs) are attractive candidate biomarkers to the clinic.
Objectives
Based on a comprehensive review of the relevant literature in the field, we explore the potential of miRNAs as biomarkers to answer relevant clinical dilemmas...
Background
Currently, the precise mechanisms that underline male infertility are still unclear. Accumulating data implicate non‐coding RNA cargo of seminal plasma extracellular vesicles due to their association with poor semen quality and higher expression levels relative to vesicle‐free seminal plasma.
Method
We assessed sperm‐free seminal plasma extracellular vesicle non‐coding RNA profiles from...
Aim
This study is performed to analyze the role of long non‐coding RNA plasmacytoma variant translocation 1 in prostate cancer.
Methods and materials
Plasmacytoma variant translocation 1, miR‐515‐5p, and high mobility group B3 mRNA expressions were examined using quantitative real‐time polymerase chain reaction and immunohistochemistry. After gain‐of‐function and loss‐of‐function models were established,...
Background
It has been estimated that microorganisms are involved in the pathogenesis of approximately 20% of all cancers. Testicular germ cell tumours (TGCTs) are the most common type of malignancy in young men and arise from the precursor cell, germ cell neoplasia in situ (GCNIS). The microbiome of seminal plasma and testicular tissue has not been thoroughly investigated in regard to TGCTs.
Objectives...
Background and objectives
Predicting the origin of azoospermia with non‐invasive biomarkers is clinically relevant for determining the chance of successful sperm retrieval from the testes before attempting assisted reproduction treatment. Here, the semen small extracellular vesicle microRNA miR‐31‐5p‐based biomarker test to distinguish obstructive azoospermia from secretory azoospermia (previously...
Background
Analyses of small non‐coding RNA (ncRNA) expression in malignant germ cell tumours (GCTs) have focused on microRNAs (miRNAs). As GCTs all arise from primordial germ cells, and piwi‐interacting RNAs (piRNAs) have important roles in maintaining germline integrity via transposon silencing, we hypothesised that malignant GCTs are characterised by fundamental piRNA dysregulation.
Aims
We...
Introduction and objective
Conventional serum tumor markers (STMs) for testicular germ cell tumors (GCTs) offer limited performance with particularly poor sensitivity in cases of minimal residual disease and pure seminoma. While growing evidence has indicated miR‐371a‐3p to be a superior biomarker, its utility in detecting pure seminoma at recurrence has not been extensively explored. This study's...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.